The Impact of Vaccination on COVID-19 Outcomes in Vietnam

Project Description

Objective: To evaluate the effectiveness of COVID-19 vaccination on clinical outcomes among patients in three hospitals in Vietnam.
Study design: Observational study involving 3,102 confirmed COVID-19 patients.
Participants were categorized based on vaccination status:
- Unvaccinated
- Partially vaccinated (PV) – one dose
- Fully vaccinated (FV) – two doses
- Boosted – three doses
Key outcomes measured:
- Mortality
- Hospital stay duration
- Persistent post-treatment symptoms
Analytical method: Regression modeling was used to analyze the relationship between vaccination status and outcomes.

Vaccination rates:
- Unvaccinated: 43.39%
- PV: 4.63%
- FV: 43.93%
- Boosted: 8.05%
Comorbidities: 48% of patients had at least one chronic condition.
Severe disease was significantly more common in the unvaccinated group.
Biomarkers of organ injury, such as AST, ferritin, troponin T, proBNP, D-dimer, and urea, were elevated in unvaccinated and PV patients, indicating greater physiological stress and damage.
Age was the strongest predictor of critical illness, followed by:
- Vaccination status
- Hypertension
- Diabetes
- Heart disease
- Chronic kidney disease
Mortality rates:
- Unvaccinated: 5.2%
- Fully vaccinated: 1.4%
- Boosted: 0.3%

Provided real-world evidence on the protective impact of COVID-19 vaccines in a Vietnamese hospital setting.
Demonstrated that vaccination reduces disease severity, shortens hospital stays, and lowers mortality, especially in older adults and those with chronic illnesses.
Identified key predictors of severe COVID-19, supporting targeted healthcare strategies for high-risk groups.

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